Dr. Robert Mignacca joined Children’s Hospital Central California in 1996 and is the Medical Director of Hematology and Acting Medical Director of Oncology. He has particular expertise in treating patients with sickle cell disease, thalassemia, hemophilia, thrombophilia and rare hematologic disorders. He has a special interest in contributing to the Center for Disease Control’s ongoing Universal Data Collection project for patients with bleeding disorders, which he has participated in since 2001.

Dr. Mignacca is board certified in Pediatrics and Pediatric Hematology/Oncology by the American Board of Pediatrics. In addition to seeing patients, he serves on the clinical faculty of University of California, San Francisco. Dr. Mignacca is a member of the American Academy of Pediatrics, National Hemophilia Foundation and the Children’s Oncology Group. He is also conversant in Spanish.

After graduating from Saint Louis University in Saint Louis, Missouri, Dr. Mignacca completed his internship and residency in pediatrics at Childrens Hospital of Los Angeles. He completed a fellowship in pediatric hematology/oncology at the University of California, Los Angeles Medical Center.

Publications

Singer ST, Wu V, Mignacca R, Kuypers FA, Morel P, Vichinsky EP. “Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly asian descent.” Blood. 2000; 96(10):3369-73.
PMID: 11071629

Mignacca RC, Lee HJ, Kwon EM, Sakamoto KM. “Mechanism of transcriptional activation of the immediate early gene Egr-1 in response to PIXY321.” Blood. 1996; 88(3):848-54.
PMID: 8704240

Lee HJ, Mignacca RC, Sakamoto KM. “Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133.” J Biol Chem. 1995;270(27):15979-83.
PMID: 7608156

Sakamoto KM, Mignacca RC, Gasson JC. “Signal transduction by granulocyte-macrophage colony-stimulating factor and interleukin-3 receptors.” Receptors Channels. 1994; 2(3):175-81.
PMID: 7874444